A genetic polymorphism of IL- 7(rs964373) in bacterial vaginitis in Iraqi women patients

Abstract

Bacterial vaginosis (BV) is the most widespread, alteration of vaginal micro flora worldwide. We aimed to investigated between the polymorphism of the single nucleotide of the gene interleukin-7(SNP rs964373) where samples were collected blood from Pregnant women patients with BV Genomic DNA was obtained from 75 BV positive patients, and 25 not Pregnant women as a control. Analysis of Hardy-Weinberg equilibrium (HWE) in BV patients and controls revealed that the IL-7 genotypes were agree with the equilibrium, and no significant differences (p = 0.8230, 0.6307) were observed between the observed and expected genotype frequencies. We demonstrated that women who were homozygous CC genotype and C allele were risk for BV, with an OR =(2.18)   and ( 2.13)   also  the heterozygous    CT, were risk factor while homozygous TT and allele T were preventive factor  for BV ,with OR( 0.37) ,(0.46) respectively in the rs9643739. In conclusion, the results of the study indicate that IL-7 SNP showed associations finding of our study was that the rs9643739 was associated with a higher risk of BV progression in women of Iraqi patients