Cardiovascular Diseases and Relationship with Mortality and Severe COVID-19 in Patients with COVID- 19: A Systematic Review and Meta-Analysis


  • Fariba Hosseinzadegan, Sepideh Sarlak, Solaleh Savoji, Seyed Amir Ashkan Mousavi Chashmi, Mahnaz Sadeghian


COVID-19, Cardiovascular Diseases, Mortality, Severe COVID-19


Background and aim: the purpose of present study was Evaluation of cardiovascular diseases and its relationship with mortality and severe COVID-19 in patients with COVID- 19.

Method: all articles published in international databases such as PubMed, Scopus, Science Direct, Embase between January 2019 and March 2022 included. Google Scholar search engine was used; Used PECO strategy to answer the research questions. Data analysis was performed using STATA.V16 software.

Result: In the initial search, 481 studies were identified; full text of 139 articles was reviewed; finally, thirteen articles entered the analysis. Risk ratio of correlation between cardiovascular diseases and mortality and severe COVID-19 in compared between outcome (+) and outcome (-) group was 0.77 (RR; 95 CI (0.51, 1.03), p=0.00) and 0.68 (RR; 95 CI (0.49, 0.88), p=0.00), respectively. 

Conclusion: cardiovascular diseases are associated with an increased risk of poor outcome in patients with COVID-19 and can increase the severity of COVID-19 and mortality