Effect of bariatric procedure types on Nonalcoholic steatohepatitis in morbidly obese patients: a systematic review and meta-analysis

Authors

  • Behnamreza Makhsousi, Mohammadsaeid Kahrizi., Bashir Emami, Somaieh Khodayarpourgolestani, Jalal Nourmohammadi, Masoud Gharaeijomehei

Keywords:

Morbid Obese Patients, bariatric surgery, steatosis, steatohepatitis, fibrosis

Abstract

Purpose: Determine effect of bariatric procedure types on Nonalcoholic steatohepatitis in morbidly obese patients

Method: The initial search was based on relevant keywords in the electronic databases PubMed, Scopus, Web of Science, EBSCO and Embase between 2011 to September 2021. The mean difference and effect size was calculated with 95% confidence interval (CI) by fixed effect model and inverse variance method. Meta-analysis was performed using Stata / MP v.16 software.

Result: Overall Mean differences of BMI between after and before bariatric surgery in Morbid Obese patients was -12.19 (MD, 95% CI -12.73, -11.65). Overall effect size of improves nonalcoholic fatty liver disease after surgery in Morbid Obese patients was 55% (MD, 95% CI 51%, 60). Based on findings, significantly improves nonalcoholic fatty liver disease after bariatric surgery observed.

Conclusion: bariatric surgery can significantly improve the histological and biochemical manifestations of non-alcoholic fatty liver disease. Roux-en-Y gastric bypass was more effective than other surgical procedures.

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Published

2022-04-12