Evaluate relationship between various clinical outcomes with severe outcomes from COVID-19: systematic review and meta-analysis


  • Shahaboddin Mashaei, Mahnaz Sadeghian, Seyedeh Marziyeh Siasi Nejad, Mahdieh Khodabandeh, Shima Sadat Aghahosseini


vital signs, clinical outcomes, COVID-19, severe COVID, severe outcomes


Background and aim: the purpose of present study evaluate relationship between various clinical outcomes with severe outcomes from COVID-19.

Method: Current study following the PRISMA guidelines, all articles published in international databases such as PubMed, Scopus, Science Direct, Embase between January 2019 and March 2022 included. 95% confidence interval on odds ratio were done with random effect model and Restricted maximum-likelihood method. Data analysis was performed using STATA.V16 software

Result: In the initial search, 842 studies were identified; the full text of 182 articles was reviewed; finally ten articles entered the analysis. Odds ratio of Hypertension between Severe and mild groups was 1.70 (OR; 95 CI (1.07, 2.33); p=0.00). Diabetes was significantly associated with COVID-19 severity (p=0.00). Odds ratio of active Cancer between groups was 1.90 (OR; 95 CI (1.21, 2.59); p=0.00). The most vital signs associated with the severity of COVID-19 infection were Respiratory Rate and Oxygen saturation.

Conclusion: The present findings show that evaluation and determination of vital risk factors in patients with COVID-19 can be effective in immediate action of the medical staff; it also changes individual behavior, classifying the risk of COVID-19.