Histopathological Changes of Rabbits’ Vital Organs Associated with Corynebacterium Pseudotuberculosis Infection

Abstract

Study the effect of the Corynebacterium pseudotuberculosis killed and sonicated antigens occurred in some vital organs of the laboratory animals was performed. It was noticed that the antigens’ influence was considerable on the animal’s health after limited period of time. This assessment occurred throughout histopathological evaluation for heart, brain, skin, kidney and urinary bladder tissues. The cardiac tissues revealed intramuscular hemorrhage and congestion with moderate hyalinization of adjacent myocytes. Whereas examining brain tissues revealed moderate to severe damage at the meningeal blood and brain cells, besides, sever vacuolation with proliferation of neuroglin cells noticed at the histopathological sections. Relative to that, skin expressed showed focal cellular aggregation within necrotic debris appeared in deeper region of dermal sub-cutaneous tissue accompanied by aggregation composed mainly of lymphocyte. For the kidney tissues, they were expressed moderate to severe vacuolation of tubular epithelial lining with mild cystic tubular dilation containing haemogenous substance as an evidence for the presence of severe tubular necrosis in addition to sloughed epithelial and an intense swelling in the major tubules accompanied by aggregation of mononuclear cells. Also urinary bladder examination proved that it was respond to outside stimuli. All these findings proved that C. pseudotuberculosis antigens given was pathologically affective.