Effects of Perioperative Systemic Corticosteroids on Clinically Significant Outcomes in Patients Undergoing Maxillofacial Trauma Surgery: A Systematic Review and Meta-Analysis

Authors

  • Hamed Mahmoudi, Elham Sadat Afraz, Zahra Nasiri, Milad Parvin

Abstract

Background and aim: Maxillofacial injuries are frequent cause of presentations in an emergency department. The present study was performed to evaluate the effects of Perioperative Systemic Corticosteroids on Clinically Significant Outcomes in Patients Undergoing Maxillofacial Trauma Surgery.

Method: Databases of PubMed, Scopus, Web of Science, EBSCO and Embase were searched for systematic literature between 2010 to August 2021.  For Data extraction, two reviewers blind and independently extracted data from abstract and full text of studies that included.95% confidence interval for odds ratio with fixed effect model and Mantel-Haenszel method were calculated. To deal with potential heterogeneity, random effects were used and I2 showed heterogeneity. Meta-analysis was performed using Stata/MP v.16 software (The fastest version of Stata).

Result: In the initial review, duplicate studies were eliminated and abstracts of 134 studies were reviewed, the full text of 21 studies was reviewed by two authors, finally, eight studies were selected.  Odds ratio ofpostoperative nausea and vomitingbetweencorticosteroid and control group was -0.76 (OR, -0.76 95% CI -1.54, 0.02; p=0.06).Odds ratio ofadverse effects betweencorticosteroid and control group was 1.22 (OR, 1.22 95% CI 0.36, 2.07; p=0.01).

Conclusion: Based on the findings of the present meta-analysis, significant differences were observed about adverse effects such asinfection, and wound healing complications between Perioperative Systemic Corticosteroids and not useCorticosteroids groups.

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Published

2022-04-21