An Understanding in Etiopathogenesis of Vitiligo based on Melanin Synthesis - A single case study report


  • A. Lazha, G. Puthilibai, M. Anbuthangam, V. Devatarika, S. Mathukumar


Vitiligo is a melanin depigmented disorder marked itself by getting higher depigmented lesions of the Skin. Vitiligo occurs worldwide, with a prevalence of 0.5 to 2%. It is characterized by the occurrence of non-pigmented areas of irregular shape, which develop on the epidermis of skin and hair. The causes of skin diseases are based on External Environmental agents like Physical, Chemical, Biological and Internal Environmental agents like diet, mind, endocrine, metabolic, nutritional, immunological and drugs. Primarily Melanin pigment is responsible for hair, eye and skin pigmentation in humans is produced by melanocytes through a complicated process called melanogenesis that is catalyzed by tyrosinase and other tyrosinase-related proteins. This article aims to study about etiopathogenesis of vitiligo based on melanin synthesis that occurs in melanocytes such as to explain about deficiency of necessary factors for melanin synthesis. This clinical study reveals that there is a decreased amount of melanin pigment present in the white patches of vitiligo by Histopathological study of skin biopsy.