The role of allergic mediators and correlation with immune cells in patients with Allergic Rhinitis

Abstract

Introduction: Allergic rhinitis (AR) is the most common form of non-infectious rhinitis, induced after allergen exposure by an immunoglobulin E (IgE)-mediated activation of mast cells (MCs) in leading to mediators release and accumulation of inflammatory cells in the nasal mucosal membrane. Objective: Determine the correlation between serum level of allergic mediators, blood immune cells, and AR reaction. Methods: Based on the frequency and duration of symptoms, 60 samples obtained from individuals with AR were classified as persistent and intermittent. As a control group, 30 samples were taken from participants who did not have any allergies, inflammation, or chronic conditions. Results: The results showed a highly significant elevation (p < 0.01) in the serum levels of IgE and (p < 0.05) in the serum levels of eosinophil cationic protein (ECP) and tryptase in both AR patients compared with healthy individuals. There was a significant increase in blood eosinophil count (p < 0.05) in both AR patient groups compared with the control group. While there is no significant difference in blood lymphocyte and neutrophil cell count between AR patients and the control group