To Evaluate the Correlation of Second Trimester Maternal Serum Alphaprotein in 14-22 Weeks and Adverse Pregnancy Outcome

Abstract

Aim: To evaluate the correlation of Second Trimester Maternal Serum AlphaproteinIn 14-22 Weeks and Adverse Pregnancy Outcome.

Materials and methods: This prospective observational study was carried out in the Department of Obstetrics and Gynaecology,180 pregnancies women were reviewed by the maternal serum alpha-fetoprotein screening program. The age and weight of all pregnant women were 20-30 years old at conceptions and 55-70kg respectively. Participants are ideally screened between 14-22 weeks' gestation.

Results: 180 pregnant women between the 14th and 22th weeks of gestation were evaluated. The mean age of the participants was 24.7±3.01 years. The mean of the birth weight was 3057±510 gram (1700-4340gram). The mean maternal serum Alpha- fetoprotein was 44.57±39.2 ng/cc (2.3-250 ng/cc). The median MSAFP was 34 ng/cc. Of 180 pregnant women, 150 had without preterm labor and 30 had preterm labor .The frequency of pregnant outcomes were as following: 5 (1.01%) stillbirths, 30(16.677%) preterm labor, 9(5%) PROM, 14(7.78%) pre-eclampsia, 25(13.89%) oligohydramnious, 2(1.11%) miscarriage. There was a correlation between preterm labor and higher MSAFP. The mean was 53.14 ng/cc in preterm labor and 35.13 ng/cc in term labor (P- value~0.021). The mean MSAFP was 75.16 ng/cc in pre-eclamptic women while it was 40.75 ng/cc in pregnant women without pre-eclampsia. Therefore, second trimester MSAFP levels were significantly higher in women with pre-eclampsia (P <0.001). Also, an association was found between level of MSAFP and oligohydramnious. It was higher in pregnancy women with oligohydramnious compared with normal women (76.39 ng/cc vs. 39.61 ng/cc) (P <0.001). The association between low birth weight and the levels of MSAFP was significant. With increasing MSAFP between 14-22 weeks' gestation, birth weight decreased (P <0.001).

Conclusion: We concluded that the elevated MS-AFP is associated with increased risks of APOs. ONTDs complicate merely a small proportion of pregnancies with elevated MS-AFP, and the rest of them have high risks of obstetric complications.