Assessment of Liver Dysfunction in Acute Dengue Infection

Abstract

Background:Dengue is a febrile illness caused by infection with 1 of 4 dengue viruses transmitted by the Aedes mosquito. Liver involvement in the form of abnormalities in liver function test is commonly seen in dengue fever. The present study was conducted to assess liver dysfunction in acute dengue infection.

Materials & Methods:72 patients of dengue infection of both genderswere categorized in to classical dengue fever (DF) (group I), Dengue hemorrhagic fever (group II), Dengue shock syndrome (group III) as per WHO criteria. Dengue infection was detected using Rapid test (Immunochromatography) for Dengue NS1 Antigen/IgM Dengue. Assessment of SGOT, SGPT, T. Bilirubin, serum albumin, S. alkaline phosphatase and INR level was done

Results: Out of 72 patients, males were 56 and females were 16. The mean SGOT level was 690.4 U/L, SGPT was 284.2 U/L, T. bilirubin was 0.96 mg/dl, s. albumin was 4.11 g/dl, alkaline phosphatase level was 115.6 U/L, INR was 1.4. The mean SGOT level was 564.2 U/L, 610.2 U/L and 690.4 U/L, SGPT was 114.5 U/L, 214.5 U/L and 284.2 U/L, T. bilirubin was 0.45 mg/dl, 0.60 mg/dl and 0.96 mg/dl, s. albumin was 3.21 g/dl, 3.89 g/dl and 4.11 g/dl, alkaline phosphatase level was 78.2 U/L, 102.4 U/L and 115.6 U/L, INR was 1.1, 1.3 and 1.4 in group I, II and III respectively.

Conclusion: Liver dysfunction with raised SGOT/SGPT was seen in almost all patients. More raised values were seen in patients with dengue shock syndrome.